South Asia houses around quarter of the global population and more than one-third of the world’s poor. The per capita income remains lowest. Except for Maldives, where the major industry is tourism and fishing, South Asian economy remains largely agricultural. Industries like textiles and IT have made significant gains recently. The region has the greatest development needs as four LDCs (Bangladesh, Bhutan, Maldives and Nepal) lie in the region. Economy being largely dependent on agriculture is highly vulnerable to climate change. Most of the countries also suffer huge trade deficits. Sustaining economic growth, reducing poverty and inequality, creating empowering jobs, fighting climate change and disasters, ensuring food security and nutrition, health of oceans and loss of biodiversity, besides violence and grave situation of human rights, governance and corruption remains big challenges. The sub region with the multiple challenges, low resilience and scarce means of implementation will have to work harder to achieve Sustainable Development Goals.